Better and more personal cancer risk estimates for patients with PTEN hamartoma tumor syndrome
For counselling and treatment of patients with the PTEN hamartoma tumor syndrome (PHTS), it is important to know what the cancer risks are in these patients. We previously showed that it is important to have better and more personal cancer risk estimates. Therefore, we performed the INSPECT study.
This large study gives better and more personal estimates for the cancer risk. The INSPECT study shows that for females with PHTS the risk on breast cancer at 60 years of age is most likely between 54% and 76%. For endometrial cancer the risk at 60 years of age is between 6% and 22%, and the risk for thyroid cancer at 60 years of age is between 10% and 23%. For males with PHTS, the risk of thyroid cancer at 60 years of age is between 8% and 18%. For other cancer types that can develop in PHTS patients, such as colorectal cancer, kidney cancer and melanoma, the risks at 60 years of age are all lower than 10%.
The results of this study give better and more personal cancer risk estimates for PHTS patients. This is very important information for the counseling and treatment of PHTS patients.